Machine Learning Scientist (Genomics)

Machine Learning Scientist (Genomics)

Who we are:

Life Reimagined

Constructive Bio is a VC-backed biotechnology start-up based in Whittlesford, Cambridge. Our breakthrough technology harnesses the power of genome rewriting and genetic code reprogramming to make valuable products that positively impact the world. We will use our platform to turn cells into bio-renewable factories to produce novel molecules that were previously inaccessible to natural biology, with diverse applications in industries spanning healthcare, biological research, materials and electronics. 

Constructive Bio is a spinout from Professor Jason Chin's laboratory at the MRC Laboratory of Molecular Biology in Cambridge. Learn more about the Chin lab achievements here: https://www2.mrc-lmb.cam.ac.uk/ccsb/jason-chin/

We want to build a team with trust and respect for each other and create a culture of collaboration, openness, curiosity, and scientific excellence. 

We are built on three principles:

• We imagine: We think big and plan our own path for success.


• We pioneer: We take action and grow together as one to break moulds.


• We deliver: We take ownership and work together to deliver excellence.

Overview of role 

We are looking for a Machine Learning Scientist to join our bioinformatics team. The successful candidate will be responsible for leveraging genomic data, together with AI/ML and other computational approaches, to drive our genome design platform. The ideal candidate will have a demonstrated track record of delivering AI/ML solutions for complex biological problems; they will be a creative, clear thinker who thrives in multidisciplinary environments. As an early member of the team, you would have the opportunity to make a big impact on the development of our platform.  

Responsibilities: 

• Development and deployment of computational approaches for the design of synthetic DNA sequences. 

• Collaborate closely with experimental colleagues and the wider computational team to design experiments, and build large AI/ML datasets, to inform the above. 

• Contribute to the company’s AI/ML roadmap, ensuring alignment with the technical and commercial goals of our platform development. 

• Stay up to date with the state-of-the-art in deep-learning and other computational approaches to synthetic DNA sequence design. 

• Regularly communicate progress, results and challenges with the wider R&D team. 

Requirements: 

• A PhD or Master’s degree in Bioinformatics, Computational Biology, Computer Science, Life Sciences or similar, with hands on experience applying AI/ML techniques to genomic data (PhD preferred). 

• Demonstrated experience of working in an AI/ML-related role in the life sciences industry. 

• Solid understanding of AI/ML methods, deep-learning architectures and statistics 

• Experience in working with Python, including with common deep-learning frameworks (eg, PyTorch). Sufficient software engineering skills to build tools others can use. 

• Strong problem-solving skills and the ability to work independently in a fast-paced environment 

• Excellent written and oral communication skills and ability to work collaboratively in a team 

Desirable: 

• Experience working with large, generative AI models (e.g. language/structure), ideally in the biomolecule (DNA/RNA/Protein) domain 

• Familiarity with techniques for generating high throughput genotype-phenotype datasets, such as deep mutational scanning 

• Experience of deploying ML models in a cloud computing environment 

What’s in it for you? Why work at Constructive Bio?

We are a small but rapidly growing team - as an early member, you will be immersed in different aspects of the early company set up and there will be ample opportunities for personal development. This is a unique chance to make a big impact in our platform and company culture. We have recently moved to our new modern offices located in Whittlesford, near Cambridge which offers on-site parking. In addition, we offer a competitive benefits package which includes Private Healthcare and a generous pension contribution.

Constructive Bio is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.